Antiproliferative and hepatoprotective activity of metabolites from Corynebacterium xerosis against Ehrlich Ascites Carcinoma cells

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Antiproliferative and hepatoprotective activity of metabolites from Corynebacterium xerosis against Ehrlich Ascites Carcinoma cells.

OBJECTIVE To find out the effective anticancer drugs from bacterial products, petroleum ether extract of Corynebacterium xerosis. METHODS Antiproliferative activity of the metabolite has been measured by monitoring the parameters like tumor weight measurement, tumor cell growth inhibition in mice and survival time of tumor bearing mice, etc. Hepatoprotective effect of the metabolites was dete...

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Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English is a dioeciously climber plant grown in India and used traditionally for various medicinal purposes. Present study evaluated antiproliferative effect of hydroalcoholic extract from T. dioica root (TDA) on Ehrlich ascites carcinoma (EAC) cells in vitro. The cytotoxic activity of TDA (1 to 10 μg/ml) against EAC cells was ...

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Antitumor Activity and In Vivo Antioxidant Status of Mucuna Pruriens (Fabaceae) Seeds against Ehrlich Ascites Carcinoma in Swiss Albino Mice

The aim of the present study is to evaluate the antitumor effect and antioxidant role of Mucuna pruriens (Family: Fabaceae) against EAC bearing Swiss albino mice. The effect of methanol extract of Mucuna pruriens (MEMP) on tumor growth and hosts survival time was studied by the following parameters: tu-mor volume, packed cell volume, viable and non-viable cell count and life span of the host. M...

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Drug delivery systems such as nanoparticles are used to improve the pharmacological and therapeutic properties of anticancer drugs. In this study, a biodegradable polymer chitosan (CS) was used for delivery of cyclophosphamide (CP). Cyclophosphamide loaded chitosan nanoparticles (CP-CS-NPs) were prepared by ion cross-linking to form a uniform particle size of 186.53 ±1.865 nm with 78±2.67 % ent...

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Objective: Present investigations were carried out for evaluation of antitumor and in vitro antioxidant activity of ethanol and aqueous extracts of Jasminum angustifolium Linn. Methods: For its antitumor activity, Ehrlich ascites carcinoma (EAC) induced swiss albino mice were used and were divided into five group with 6 animal each.The antitumor effect was assessed using viable tumour cell coun...

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ژورنال

عنوان ژورنال: Asian Pacific Journal of Tropical Biomedicine

سال: 2014

ISSN: 2221-1691

DOI: 10.12980/apjtb.4.2014c1283